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Prabhat Pathak
Senior Scientist - Engineering at Merck
Professional Background
Prabhat Pathak is a distinguished life science professional with over a decade of extensive experience in biopharmaceutical research and development (R&D) and manufacturing. He has specialized in the field of protein purification process development, showcasing a robust and efficient approach to creating scalable processes that are crucial for therapeutic protein production. Prabhat's career reflects a solid commitment to advancing the biopharmaceutical industry, especially within the realms of process characterization, scale-up design, and technology transfer.
Prabhat's professional journey has taken him through key roles that have enriched his expertise in the downstream processing of therapeutic proteins. His current position as a Senior Scientist in Engineering at Merck places him at the forefront of biopharmaceutical technology, where he typically handles complex projects that require adept leadership and technical proficiency. Notably, he has gained significant experience in Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP), ensuring that the highest standards of quality are upheld in every aspect of the research and manufacturing processes.
Prabhat possesses strong technical skills, particularly in utilizing state-of-the-art equipment such as the GE FPLC system, tangential flow filtration (TFF), and various chromatography techniques. His ability to work with both microbial and mammalian expression systems has allowed him to contribute meaningfully to the development of multiple therapeutic proteins and monoclonal antibodies, including Bevacizumab, Palivizumab, and Etanercept.
Education and Achievements
Prabhat Pathak boasts a comprehensive educational background, having earned a Doctor of Philosophy (Ph.D.) in Protein Crystallography from Oklahoma State University. His academic journey does not stop there; he has also acquired a Master's degree in Industrial Biotechnology from Chaudhary Charan Singh University, and a Master of Science (MS) in Biochemistry and Molecular Biology from Oklahoma State University. Additionally, he holds a Bachelor of Science degree in Chemistry from the Institute of Science, Banaras Hindu University.
Throughout his career, Prabhat has been involved in a myriad of aspects relating to biopharmaceutical development, and his contributions have been recognized within the industry. His leadership acumen includes managing teams, overseeing multiple projects simultaneously, and ensuring that product delivery meets stringent timelines. This experience has equipped him with the necessary skills for effective communication across departments, ranging from R&D to Quality Control (QC), Quality Assurance (QA), regulatory affairs, and manufacturing.
Prabhat has authored comprehensive protocols, standard operating procedures (SOPs), work plans, and reports critical for Biologics License Application (BLA) submissions. These contributions underscore his profound understanding of regulatory guidelines, including cGMP and FDA regulations (21 CFR Part 210/211) as well as International Conference on Harmonization (ICH) guidelines.
Notable Achievements
Throughout his impressive career, Prabhat has garnered several notable achievements:
- Successfully participated in process characterization and scale-up for several biopharmaceutical products, resulting in enhanced efficiency and effectiveness in manufacturing processes.
- Developed analytical methods to characterize proteins and detect impurities, significantly contributing to the quality assurance of therapeutic proteins.
- Led a multidisciplinary team to navigate challenges in biopharmaceutical development, ensuring cohesive interdepartmental collaboration that streamlined operations and improved timelines.
- Played a pivotal role in instrument procurement and laboratory setup for start-up organizations, demonstrating entrepreneurial spirit and foresight in the biopharmaceutical sector.
- Collaborated on the development and optimization of monoclonal antibodies and recombinant molecules, providing critical insights into their efficacy and production viability.
In summary, Prabhat Pathak is a highly accomplished life science professional whose decade-long career has been dedicated to the biopharmaceutical industry. His expertise in protein purification, process development, and regulatory compliance continues to set the groundwork for future advancements in therapeutic proteins. With a strong emphasis on leadership and communication, Prabhat consistently delivers on the expectations of his projects and teams while fostering innovation and collaboration across various sectors of the industry.
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