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Pierce Ogden
Co-Founder and CSO at Manifold Bio
Pierce Ogden is the Co-Founder and Chief Scientific Officer (CSO) at Manifold Bio, a biotechnology company specializing in the design of precision biologics. He has been with Manifold Bio since its inception in 2019, where he has played a pivotal role in developing the company's innovative protein M-Codes technology. This technology allows for advanced measurements of protein therapeutics in vivo, significantly enhancing drug discovery processes.13
Educational Background
Pierce Ogden earned his Doctor of Philosophy (Ph.D.) in Biological and Biomedical Sciences from Harvard University in 2019. His academic journey also includes a Bachelor of Science degree in Biochemistry and Molecular Biology from the University of San Francisco.15
Professional Experience
Before co-founding Manifold Bio, Ogden held several notable positions:
- Postdoctoral Research Fellow at the Wyss Institute for Biologically Inspired Engineering, where he focused on using DNA libraries and machine learning to develop next-generation protein therapeutics.12
- PhD Candidate in the George Church Lab at Harvard Medical School, where he worked on engineering viral structures and immune system responses for gene therapy applications.12
- Assistant Specialist at the Small Molecule Discovery Center at UCSF, where he developed assays for identifying new compound interactions.15
Contributions to Biotechnology
At Manifold Bio, Ogden has led efforts to create extensive protein binder and M-Code libraries using machine learning and advanced DNA synthesis techniques. His work has contributed to raising approximately $45 million in funding to support the company's growth and technological advancements.136
Ogden's research focuses on leveraging synthetic biology to enhance drug development, particularly through the use of adeno-associated viruses (AAVs) for gene therapy. His pioneering work aims to improve the delivery mechanisms of these therapies, making them safer and more effective.24
Overall, Pierce Ogden's expertise in synthetic biology and high-throughput methods positions him as a key figure in advancing the field of biotechnology and therapeutic development.