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    Ben Chih

    Neuroscientist, Entrepreneur In Residence

    Professional Background

    Ben Chih is a highly skilled translational scientist with a robust background in target validation and drug discovery, specifically focusing on early development activities within the pharmaceutical industry. With a remarkable track record of advancing over 11 pipeline projects across various modalities—including biologics, small molecules, and antisense oligonucleotides—Ben has proven to be an invaluable asset in the mission to develop novel therapeutics. His leadership capabilities shine as he orchestrates cross-functional project teams through critical phases of molecule discovery and development, utilizing a comprehensive approach that includes in vitro human induced pluripotent stem cell (iPSC) disease modeling and pharmacology.

    His expertise spans pre-clinical in vivo rodent disease model proof of concept (PoC), biomarker discovery, and non-human primate studies focused on establishing mechanisms of action (MOA) and complex pharmacokinetic/pharmacodynamic (PK/PD) relationships. Ben's dedication to advancing scientific knowledge and improving patient outcomes underpins his professional journey.

    Education and Achievements

    Ben Chih pursued his Ph.D. in Neuroscience at the prestigious Columbia University Vagelos College of Physicians and Surgeons, where he honed his skills and deepened his understanding of various neurobiological mechanisms. His academic journey began with a Bachelor of Science in Biology at Carnegie Mellon University, laying a solid foundation for his career in science. Through his education, Ben has gained a profound comprehension of cellular and molecular biology, providing him with the tools necessary to excel in complex scientific research settings.

    Throughout his extensive career, Ben has had the opportunity to work with several renowned organizations, including:

    • Alloy Therapeutics, Inc. as an Entrepreneur In Residence, where he leverages his scientific expertise to foster innovation in the biotechnology sector.
    • Genentech, one of the world’s leading biotechnology companies, where he served as a Senior Scientist and made significant contributions to the advancement of therapeutic agents.
    • Igenica, where as a Scientist II, he continued to broaden his experience in drug development.
    • Elan Pharmaceuticals, as a Scientist, Ben was involved in critical research that shaped the future of drug discovery.
    • Genentech again as a Postdoctoral Fellow, further building on his research prowess.
    • He also gained valuable experience as a Graduate Student at Columbia University Medical Center and as a Research Associate at the prestigious California Institute of Technology (Caltech).

    Specialties

    Ben's specialties reflect his multifaceted expertise within the field of translational science. They include:

    • Synapse Biology: Understanding the intricate workings of synaptic connections, which is essential for developing therapies targeting neurological disorders.
    • Neurodegeneration and Neuroinflammation: Addressing critical aspects of diseases that lead to cognitive decline and are prominent in conditions such as Alzheimer’s and other neurodegenerative diseases.
    • Blood-Brain Barrier Transport: Developing strategies to facilitate effective delivery of therapeutic agents across this formidable barrier.
    • Human iPSC Technology: Utilizing patient-derived stem cells for disease modeling, which aids in personalized medicine approaches.
    • Neuron and Microglial Cell Biology: Investigating the roles of these cells in health and disease, which is pivotal for understanding neurological conditions.
    • Pharmacology and Pharmacodynamics: Focusing on drug action and effects within the body to inform treatment plans.
    • Biomarker Assays: Developing and validating biomarkers that serve as indicators for disease progression or treatment response.
    • Pre-Clinical Modeling: Applying various models to predict how potential therapeutic agents would perform in human trials.
    • CRO Management: Effectively managing contract research organizations to ensure the successful execution of research projects.
    • Microscopy and High Throughput Automation Technology: Using advanced imaging techniques and automation to enhance experimental efficiency and data collection.

    In summary, Ben Chih possesses a wealth of experience and expertise that highlights his dedication to translational science and drug development. His commitment to advancing therapeutic innovations is evident in his successful track record and his pivotal role in shaping future healthcare solutions.

    Related Questions

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    Ben Chih
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    Location

    Millbrae, California, United States