Marian Laderoute

Marian Laderoute is a prominent figure in the field of immune system management with a special focus on 7-oxo-DHEA, DHEA, 7-keto-DHEA, cortisol, and the DHEA/cortisol ratio. Her expertise spans various areas including HIV, Alzheimer’s disease, vaccine research, functional cure approaches, prevention strategies, mCI reversal, and the impact of aging on the immune system. Marian's groundbreaking work explores the role of human endogenous retrovirus K102 (HERV-K102) particle production and HML-2 activation in host defense mechanisms, shedding light on foamy macrophages and their significance in trained immunity.

Through her innovative research, Marian highlights the crucial interplay between DHEA/cortisol levels, immunosenescence, and chronic diseases. She introduces the concept of Aminomics Therapy as a potential solution for reversing immunosenescence, offering hope in the areas of HIV, Alzheimer’s, cardiovascular diseases, and cancer. Marian's vision includes the development of a functional cure for HIV-1 by boosting HERV-K102 particle production and release in foamy macrophages, thereby addressing the root causes of immunosenescence and its implications in chronic conditions.