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Somes Das
Biophysicist/Biochemist
Professional Background
Somes Kumar Das is a highly interdisciplinary lead scientist specializing in Biophysical Chemistry, renowned for his extensive contributions to the biotechnology sector. With more than nine years of industrial experience that transcends his dissertation and postdoctoral research, Somes has emerged as a prominent figure in the fields of technology development, method innovation, assay creation, and product design. His professional journey spans over twelve years, during which he has acquired a comprehensive understanding of bio-, photo-, and electro-chemistry, honing his expertise particularly in single molecule fluorescence (SMF) and nanopore-based single channel electrophysiology (SCE) detections.
Throughout his career, Somes has developed a profound proficiency in the biochemical and biophysical characterization of essential biological components such as DNA/RNA, proteins, and lipids. His work has also encompassed the bioanalytical aspects of lipid bilayers, liposomes, micelles, and nanomaterials. His research is deeply centered on biophysical and structural analysis involving nucleic acids and proteins utilizing various nano-structured devices, with a particular focus on nanopore arrays designed for mapping, sequencing, and diagnostics applications. A significant portion of this research employs advanced fluorescence imaging techniques including Total Internal Reflection Fluorescence (TIRF), Fluorescence Correlation Spectroscopy (FCS), Förster Resonance Energy Transfer (FRET), Single Molecule Photobleaching (SMPB), and Fluorescence Recovery After Photobleaching (FRAP).
Somes has recently spearheaded the development of biomarkers and multiplexing assays based on rRNA/miRNA/DNA, alongside related nanopore array devices for point-of-care microbial diagnostics. His commitment to innovation is evidenced by his recent training in micro- and nano-fabrication processes, which has led to the creation of groundbreaking methods for analyzing membrane-protein interactions. He has excelled in understanding the conformational dynamics of oligomerization and protein subunit counting at the single molecule level on lipid membranes and living cells in a variety of nanostructured devices using the aforementioned SMF imaging and SCE techniques.
In prior roles, Somes played an integral part in the advancement of a high-throughput fluorescence microscope along with the fabrication of nano-channel chips and development of biochemical assays for sample preparation, fluorophore labeling, and the comprehensive mapping and analysis of elongated DNA molecules through high throughput imaging. His innovative prowess also led to the development of assays capable of detecting genetic variations by introducing novel fluorophore labeling schemes harnessing standard molecular biology techniques, paired with cutting-edge multi-color high sensitivity fluorescence imaging—all of which have entered the commercialization phase.
Additionally, Somes is adept at synthesizing fluorescent dyes, labeling biomolecules, as well as executing surface modifications and biomolecule immobilization on surfaces. His dedication to scientific inquiry and innovation is reflected in his impressive publication record, with over 20 peer-reviewed articles, 4 patents, and a successful track record in grant writing. As a competent project manager, supervisor, and lab coordinator, Somes thrives in collaborative environments as a true multi-tasking team player.
Education and Achievements
Somes Kumar Das laid the foundation for his impressive career with a strong academic background. He earned his Ph.D. in Biophysical Chemistry from the prestigious Indian Institute of Technology, a hub for cutting-edge scientific and technological innovation. Further enhancing his expertise, Somes obtained a Master of Science (MS) degree in Physical Chemistry from the University of Kalyani.
His professional trajectory includes influential positions at leading biotechnology and scientific research organizations. Somes formerly served as a Senior Staff Scientist at Quantapore Inc., where he contributed significantly to advancing nanopore technologies. At Nanopore Dx, he took on the role of Senior Scientist/Research Lead, directing critical research initiatives. His remarkable career also includes positions as Scientist II at the University of Kentucky and Sr. Scientist at BioNano Genomics, showcasing his versatility and depth of knowledge within the scientific community.
Somes has also played a key role in the academic sector as a Research Assistant Professor at Bowling Green State University, where he engaged in innovative research and mentorship. His time as a Research Associate at the University of Kansas Medical Center further enriched his experience, as did his tenure as an Assistant Research Scientist at Texas A&M University, where he built upon his foundational knowledge in biophysical chemistry.
Achievements
Somes Kumar Das stands out in the realm of scientific inquiry with numerous notable achievements that highlight his contributions to the field of biophysical chemistry and biotechnology. His work has resulted in the co-authorship of over 20 peer-reviewed publications, providing valuable insights and advancements within the discipline. Furthermore, his innovative spirit is demonstrated through the acquisition of 4 patents, exemplifying his capability to transform scientific concepts into marketable technologies and products.
Somes' expertise in grant writing has proven instrumental in securing funding for research initiatives, underscoring his ability to articulate scientific visions and connect them with financial support for continued exploration and innovation. As a collaborative leader, he has effectively managed various projects, successfully overseen laboratory operations, and emerged as a key figure in guiding teams toward shared goals.
Overall, Somes Kumar Das' career is marked by a strong intersection of academic rigor and industrial application, establishing him as a respected leader in biophysical chemistry and biotechnology. His innovative contributions, combined with a passion for research and a commitment to advancing scientific knowledge, continue to inspire and elevate the fields in which he operates.