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    Sara Goodwin

    Manager of Technology Development at Cold Spring Harbor Laboratory

    Professional Background

    Sara Goodwin is a distinguished NGS Sequencing Core Manager and Research Investigator who plays a crucial role within the McCombie lab at Cold Spring Harbor Laboratory. With a strong emphasis on technological development and application in Next-Generation Sequencing (NGS), Sara is at the forefront of genomic research and innovation. Her primary responsibilities include the development and adaptation of cutting-edge NGS technologies as well as other applications that drive research in the field of genomics.

    Throughout her impactful career, Sara has contributed significantly to optimizing sequencing instruments and methodologies. Notably, she has developed enhancements for the Pacific Biosciences RS instrument dedicated to large genome sequencing. Additionally, she has assessed rational pooling schemes for extensive cohort sequencing on Illumina platforms, which has implications for large-scale genomic studies. Her expertise extends to the utilization of the Oxford Nanopore MinIon, where she has pioneered applications for sequencing and error correction, demonstrating her diverse skill set in advancing sequencing technologies.

    Currently, Sara is engaged in utilizing optical mapping strategies that evaluate long structural variants in cancer lines, an essential area of research for understanding the complexities of cancer genomics. She is also employing Oxford Nanopore technology for copy number variation (CNV) detection in clinical samples, further showcasing her contributions to clinical applications of NGS technology.

    Prior to her tenure at Cold Spring Harbor Laboratory, Sara cultivated her research skills as a Research Assistant in the Anslyn and Ellington Laboratories at The University of Texas. In this capacity, her research focused on utilizing Next-Generation Sequencing protocols to analyze non-specific aptamer binding to cell surfaces, while also developing non-specific aptamer microarrays for the detection of variants related to HIV-1 reverse transcriptase. This early research experience set a robust foundation for her future endeavors in sequencing technologies and bioinformatics.

    Sara's career also spans the clinical research industry, where she served as a Clinical Research Coordinator at Hilltop Research. In this role, she managed a clinical research project to assess the efficacy of over-the-counter dermatological products. A significant project under her coordination involved testing a new product aimed at treating oral herpes simplex, showcasing her ability to merge scientific research with practical health applications. Additionally, she took on a contracted role with Dial, contributing to the coordination of clinical trials focused on the efficacy of hand sanitizer products during an era when hygiene products gained heightened importance.

    Sara’s clinical experience complements her extensive academic background, enabling her to apply her scientific knowledge effectively in both laboratory and clinical settings.

    Education and Achievements

    Sara Goodwin holds a Doctor of Philosophy (Ph.D.) in Cell and Molecular Biology from The University of Texas at Austin, with a specialized focus on Computational Biology and Bioinformatics. This rigorous academic training has given her a profound understanding of biological systems and data analysis, fortifying her role in both research and technology development within genomics.

    In addition to her Ph.D., Sara earned her Bachelor of Science (B.S.) in Molecular Bioscience and Biotechnology from Arizona State University, complemented by a minor in Anthropology. This interdisciplinary education has enabled her to approach complex biological questions with a broad perspective, integrating aspects of social sciences into her scientific endeavors.

    Achievements

    Throughout her career, Sara Goodwin has been recognized for her significant contributions to the field of genomics and bioinformatics. Her work on optimizing sequencing technologies exceeds traditional applications, pushing the boundaries of what is possible in NGS and its applications in clinical settings.

    Sara's innovations in developing new methodologies and technologies are not only recognized within academic circles but also hold potential for practical applications in clinical research, ultimately benefiting patient care and therapeutic strategies. Furthermore, her commitment to staying at the cutting edge of genomic research allows her to contribute to the ever-evolving landscape of biotechnology and healthcare.

    In summary, Sara Goodwin is a visionary in the realm of Next-Generation Sequencing, whose expertise in research and technology development continues to drive advancements in genomics. Her academic and professional journey reflects a deep commitment to enhancing the field of molecular biology, with significant implications for both research innovation and clinical applications.

    Related Questions

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    Sara Goodwin
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    Location

    Woodbury, New York, United States