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Nina Steele
Research Fellow at University of Michigan
Professional Background
Nina Steele is a passionate, motivated scientist who has dedicated her career to understanding the complex biology of cancer initiation and progression. With a strong emphasis on innovative model systems and bioinformatics, her research focuses on the critical areas that drive cancer development, specifically in gastric and pancreatic cancers. Her journey in the field of cancer research has been marked by significant contributions, including the development of novel organoid culture systems that allow for a more in-depth understanding of disease mechanisms.
After completing her undergraduate studies at Xavier University, where she earned her Bachelor of Science in Biology and Chemistry, Nina pursued her Doctor of Philosophy at the University of Cincinnati. Here, Nina's academic foundations in Physiology and Systems Biology were established, equipping her with the necessary skills and knowledge to tackle challenging questions in cancer biology. During her graduate research, she focused on the role of CD44 variant isoforms in gastric disease, illuminating pathways that could have significant implications for patient treatment and personalized medicine.
Following her PhD, Nina took her expertise further as a postdoctoral research fellow at the prestigious University of Michigan. Under the mentorship of renowned scientists Drs. Ben Allen and Marina Pasca di Magliano, she continued to explore the intricate dynamics of cancer biology. Her current research investigates the Hedgehog signaling pathway's role in pancreatic cancer progression. By focusing on this area, Nina aims to uncover potential new therapeutic approaches that combine targeting this signaling cascade with enhancing the immune response in the tumor microenvironment.
Education and Achievements
Nina Steele's educational background reflects her commitment and proficiency in the life sciences. She earned her Bachelor of Science degree from Xavier University, where her dual focus on Biology and Chemistry laid the groundwork for her future research endeavors. Further enriching her scientific acumen, she completed her PhD in Physiology and Systems Biology at the University of Cincinnati. This rigorous academic training prepared her to develop significant research in cancer biology and therapeutics.
Her transition from graduate studies to a professional research career was seamless as she took on the role of Organic Chemistry Instructor at Xavier University, an experience that not only showcased her communication skills but also solidified her understanding of the foundational concepts in chemistry that are critical to her research in cancer biology. Nina’s academic journey has been complemented by her involvement in various research positions, notably as a Research Fellow and previously at the University of Cincinnati, where she honed her experimental techniques and knowledge in pharmacology and cell biology.
Through her work, Nina has also developed novel in vitro and in vivo strategies for predicting individualized therapy responses to targeted treatments for gastric cancer. This endeavor not only highlights her innovative approach but also reflects her commitment to improving patient outcomes through personalized medicine.
Achievements
Throughout her academic and professional journey, Nina Steele has made noteworthy contributions in the realm of cancer research. Her significant work includes:
- Development of 3D Gastric Organoid Culture Systems: Nina's thesis work was groundbreaking as she created novel three-dimensional organoid models that mimic gastric tissue, facilitating a deeper understanding of gastric diseases and the effects of Helicobacter pylori.
- Therapeutic Response Prediction: She devised rapid methods for assessing individual responses to therapy for gastric cancer, paving the way for more personalized treatment strategies.
- Postdoctoral Research on Pancreatic Cancer: Currently, her research at the University of Michigan ignores advancing our understanding of the Hedgehog signaling pathway and its implications for novel therapeutic developments in pancreatic cancer, an area that demands urgent attention given the disease's aggressive nature.
- Pedagogical Contributions: Beyond her research, Nina has shared her knowledge as an Organic Chemistry Instructor, fostering the next generation of scientists.
Nina Steele’s journey is a testament to her dedication, creativity, and passion for advancing cancer research. Her commitment not only enriches the scientific community but also promises potential breakthroughs in cancer treatment that can lead to improved outcomes for patients. As she continues her research on pancreatic cancer, her efforts may open new avenues in cancer therapy, highlighting the crucial interplay between signaling pathways, immune response, and tumor microenvironments.