Nicole Bertoletti

Nicole Bertoletti, PhD, is a Postdoctoral Associate in the Joseph Schlessinger Lab at Yale University, specifically within the Department of Pharmacology. She specializes in protein crystallography, focusing on structural biology to understand protein interactions and mechanisms. Her research contributes to significant advancements in the field, particularly regarding receptor tyrosine kinases and their role in cancer biology.

Academic Background and Research Contributions

Dr. Bertoletti has an extensive publication record, with notable contributions to high-impact journals. One of her recent works includes a study published in Proceedings of the National Academy of Sciences (PNAS), where she co-authored a paper on the structural analysis of KIT and its oncogenic mutants, shedding light on potential therapeutic targets for cancer treatment.12 Her research often employs cryo-electron microscopy (Cryo-EM) techniques, which are pivotal for visualizing complex protein structures at near-atomic resolution.

Professional Affiliations

In addition to her role at Yale, Dr. Bertoletti is active in various academic communities and has been involved in committees that enhance safety and security within the academic environment.3 Her professional network includes collaborations with prominent figures in pharmacology and molecular biology, reflecting her commitment to advancing scientific knowledge through teamwork and interdisciplinary research.

Conclusion

Nicole Bertoletti's work as a postdoctoral associate is integral to understanding the molecular underpinnings of diseases, particularly cancer. Her expertise in structural biology not only contributes to academic literature but also has implications for developing targeted therapies that can improve patient outcomes in oncology.