University of Pennsylvania

Scientific Director at Incyte

Incyte

Senior Director, Translational Sciences

•	Translational Science Lead for Immuno-Oncology and Precision Medicine first in human clinical studies
•	Design and implement biomarker and companion diagnostic strategy
•	Author translational sections in protocols
•	Interface with CROs and Companion Diagnostic partners
•	Contribute to therapeutic strategy as part of cross-functional product development team

Director, Translational Sciences

•	Matrix leader of the Immuno-Oncology Medical Team within US medical affairs
•	Set US medical strategy as a project lead on Retifanlimab (anti-PD1), LAG-3 and oral PD-L1 
•	Manage Investigator Initiated Research portfolio for Immuno-Oncology within the United States
•	Initiate translational research collaborations to support data generation
•	Active core team member of the clinical development, Global Medical, Global Commercial and US Commercial teams for Retifanlimab

Scientific Director, Immuno-Oncology US Medical Affairs

• Biomarker lead from discovery through phase 1/2 for immuno-therapy, T cell redirection and novel CAR-T programs
• Design translational studies to inform understanding of immune microenvironment and its impact on response to therapies
• Lead academic collaborations to drive translational research and proof of mechanism studies

The Janssen Pharmaceutical Companies of Johnson & Johnson

Principal Scientist, Translational Research Oncology

• Serve as Discovery representative to the compound development teams to provide scientific expertise and generate preclinical translational data packages which support mechanism of action, tumor indication prioritization, novel drug combinations and identification of potential biomarkers
• Responsible for leading projects through discovery including target validation, assay development, screening and IND preparation
• Manage direct reports and thrive in a highly matrixed environment

Senior Scientist, Immuno-Oncology Discovery

• Conducted research on the biology of immune checkpoint and T cell redirection molecules
• Developed and implemented in vitro cell-based assays for screening immuno-therapeutics
• Authored technical reports and patent applications for multiple discovery programs

Scientist, Biologics Research

Probed the ability of murine and human immune cells (NK cells, macrophages, PBMC, PMN) to implement Fc effector functions (ADCC, ADCP, CDC) and cytokine release
• Co-inventor on two invention disclosures, first author on two manuscripts describing engineered protease- resistant antibodies with selective Fc effector functions

Michelle Kinder