Jeffrey Salisbury

Professor at Mayo Clinic

Jeffrey L. Salisbury, Ph.D., is a prominent Professor at the Mayo Clinic, specializing in Biochemistry and Molecular Biology. His research primarily focuses on cancer biology, particularly the role of genomic instability in tumor progression. Dr. Salisbury has made significant contributions to understanding centrosome dynamics and their implications for cancer, having been involved in pioneering studies that identified the protein centrin, a key regulator of centrosome behavior.1

Research Contributions

Centrin Discovery: Dr. Salisbury's early work led to the cloning of human centrin genes and the establishment of its crystal structure, marking it as a crucial component in centrosome regulation.
Centrosome Dynamics: His research has explored the mechanisms controlling centrosome behavior during the cell cycle, emphasizing its role in breast cancer and other malignancies.1 2
Genomic Instability: He has investigated how defects in centrosomes contribute to chromosomal instability and aneuploidy in cancer cells, uncovering mechanisms that could inform treatment strategies.1

Recent Focus

Dr. Salisbury's recent studies highlight a unique subset of tumor cells with stem cell-like properties that exhibit resistance to conventional chemotherapy but are vulnerable to targeted treatments involving Aurora-A kinase inhibitors. This research holds promise for developing innovative cancer therapies.1 2

Academic Background

Education: He obtained his Ph.D. from The Ohio State University.
Publications: Dr. Salisbury has authored numerous peer-reviewed articles and is actively involved in various research projects at Mayo Clinic.3 4

For further details, Dr. Salisbury maintains a professional profile on LinkedIn, where he connects with colleagues and shares insights related to his work at Mayo Clinic.5