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James R. Downing, M.D.
President and CEO of St. Jude Children's Research Hospital
James R. Downing, M.D. is a distinguished medical professional and leader in pediatric cancer research who currently serves as the President and Chief Executive Officer of St. Jude Children's Research Hospital.1 He assumed this role in July 2014, marking a significant milestone in his long-standing career with the institution.5
Career at St. Jude
Dr. Downing's association with St. Jude spans several decades, during which he has held various leadership positions:
- President and CEO (2014 - Present)
- Scientific Director and Executive Vice President (2004 - 2014)
- Chair, Department of Pathology (1997 - 2009)
- Member, Department of Pathology (1997 - Present)
- Associate Member, Department of Pathology (1991 - 1997)
- Assistant Member, Department of Pathology and Laboratory Medicine (1986 - 1991)1
Education
Dr. Downing received his medical education from the University of Michigan, where he earned his Doctor of Medicine (M.D.) degree. He also holds a Bachelor of Science (B.S.) from the University of Michigan-Dearborn.1
Research and Publications
As a prolific researcher, Dr. Downing has made significant contributions to the field of pediatric cancer. He has authored more than 270 papers in peer-reviewed journals, including prestigious publications such as Nature Genetics, New England Journal of Medicine, and Blood.1 His work has been instrumental in advancing our understanding of pediatric cancers and developing new treatment strategies.
Awards and Honors
Throughout his career, Dr. Downing has received numerous accolades for his contributions to cancer research and leadership in healthcare:
- Fellow of the American Association for Cancer Research (2022)
- Outstanding Achievement in Pediatric Cancer Research Award (2020)
- CEO of the Year by Inside Memphis Business (2020)
- Pediatric Oncology Award and Lecture from the American Society of Clinical Oncology (2019)
- E. Donnall Thomas Lecture & Prize from the American Society of Hematology (2017)
- Member of the American Academy of Arts and Sciences (2016)
- Member of the National Academy of Medicine (2013)1
Leadership and Vision
Under Dr. Downing's leadership, St. Jude has embarked on ambitious initiatives, including a $12.9 billion commitment to advance research and treatment of pediatric cancers.2 He is known for fostering a positive work environment, as evidenced by St. Jude's recognition as one of Glassdoor's Best Places to Work.3
Dr. Downing is not only dedicated to his professional pursuits but also maintains personal interests outside of work. He has been known to participate in cycling events, demonstrating a commitment to physical fitness and work-life balance.4
