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    Gerald Crabtree

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    Gerald R. Crabtree is a distinguished professor and researcher at Stanford University. Here are some key points about his background and accomplishments:

    Academic Positions and Affiliations

    • David Korn Professor at Stanford University School of Medicine14
    • Professor in the Departments of Pathology and Developmental Biology at Stanford5
    • Investigator at the Howard Hughes Medical Institute (1988-2021)5
    • Member of several Stanford institutes, including Bio-X, Cardiovascular Institute, and Stanford Cancer Institute5

    Research Focus and Contributions

    Dr. Crabtree's research has made significant contributions to several areas of biology:

    • Chromatin Regulation: His lab studies fundamental mechanisms of chromatin regulation and its role in development and human cancer.5
    • Signaling Pathways: He defined the Ca2+-calcineurin-NFAT signaling pathway, which is crucial for immune system function and vertebrate development.34
    • Synthetic Biology: Pioneered the development of synthetic ligands for regulating biological processes.4
    • Neurobiology: Discovered specialized chromatin regulatory complexes (nBAF complex) essential for neuron development and function.1

    Education

    • B.S. in Chemistry and Mathematics from West Liberty State College (now West Liberty University)23
    • M.D. from Temple University23

    Awards and Honors

    • Elected to the National Academy of Sciences in 199735
    • Howard Hughes Medical Institute Investigator (1988-2021)5
    • NIH Director's Award (1984)5
    • Thomas Scientific Laureate in Chemistry (2006, with Stuart Schreiber)4
    • Jacob Javits Neuroscience Investigator Award (2013)45

    Entrepreneurship

    Dr. Crabtree has been involved in founding several biotechnology companies:

    • Ariad Pharmaceuticals24
    • Amplyx Pharmaceuticals24
    • Foghorn Therapeutics2
    • Shenandoah Therapeutics4

    Throughout his career, Gerald Crabtree has made significant contributions to our understanding of gene regulation, signaling pathways, and chromatin biology, with implications for both basic science and potential therapeutic applications in cancer and neurological disorders.

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    Gerald Crabtree
    Gerald Crabtree, photo 1
    Gerald Crabtree, photo 2
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    Location

    United States