Suggestions
Anusha Mishra
Assistant Professor, Dept of Neurology Jungers Center for Neurosciences Research, Oregon Health & Science University
Professional Background
Anusha Mishra is a dedicated and accomplished scientist with a rich background in neuroscience, focusing on the fascinating relationship between neurovascular coupling and neurodegenerative diseases. Currently holding the position of Assistant Professor at Oregon Health & Science University (OHSU), Dr. Mishra's research delves into the complexities of brain function, particularly the role of astrocytes in neuropathologies. Her previous research experience includes a postdoctoral position at University College London and several pivotal roles including research assistantships at prestigious institutions like Georgia Health Sciences University and Dragon Tech Biotechnologies. Dr. Mishra has developed a robust research portfolio that underscores her commitment to understanding the intricacies of cell signaling mechanisms within the brain, aiming to innovate therapeutic strategies for central nervous system disorders.
Education and Achievements
Dr. Mishra's educational journey is marked by academic excellence. She earned her Ph.D. in Neuroscience from the University of Minnesota-Twin Cities, where she cultivated her deep interest in brain morphology and pathology. Before obtaining her doctorate, she completed her Bachelor’s Degree at Minnesota State University, Moorhead, graduating Summa cum laude in Biology and Chemistry, placing a strong emphasis on biochemistry and biotechnology. Her educational foundation is further strengthened by a Proficiency Certificate in Science focused on Biology from St. Xavier's College, Maitighar.
Throughout her career, Dr. Mishra has investigated diverse topics ranging from fish ecology to skeletal development, showcasing her innate curiosity about the workings of living organisms. However, her passion for neuroscience has driven her to investigate critical questions related to the brain’s functionality, imagination, and memory formation, which are pivotal to human experience.
Research Contributions
In her Ph.D. research, Dr. Mishra made significant strides by analyzing how pathological changes can affect the communication between cells in the retina, specifically studying how blood flow regulation is altered in disease conditions. One of her notable achievements includes identifying a drug capable of reversing the loss of neurovascular coupling in diabetic animal models, a critical finding that highlights potential interventions for related diseases.
During her postdoctoral studies, Dr. Mishra expanded her research focus to include the role of astrocytes—cells previously underestimated in their influence on neuronal activity. She uncovered vital information about how these non-neuronal cells interact with neurons to maintain normal neurovascular function, paving the way for deeper insights into therapeutic possibilities for neurodegeneration.
At OHSU, she has been instrumental in leading innovative research aimed at understanding astrocytic response to injury and disease, termed astrogliosis. Her work emphasizes the necessity of understanding astrogliosis alterations to devise new treatment strategies for central nervous system diseases. By focusing on the interplay between astrocyte functions and neuronal outputs, Dr. Mishra’s research promises to impact the development of novel therapeutics for complex neurological conditions.
Future Directions
Looking ahead, Dr. Mishra aims to continue her ground-breaking research in the dynamic field of neuroscience, focusing particularly on the implications of astrocyte function in neurodegeneration. She aspires to correlate her findings with clinical outcomes, advancing the understanding of disease mechanisms while exploring new avenues for therapeutic interventions. Her dedication to bridging laboratory research with clinical applications positions her as a prominent figure in the advancement of neuroscience and therapeutic innovation.